Here are a few tips which will enhance your Quaffing experience:

The recommended way to drink a Quaffer is as follows: after filling the glass, tilt your head back and let the juices flow. As the liquids come out of the glass, they will combine and make the shot much smoother. The last thing you taste is the chaser, so make it a good one!
Don't be afraid of taking the whole thing down at once. It may look intimidating at first, but you'll conquer your fear... and soon, you'll quaff with the best of 'em.
Chill the alcohol in the freezer - this allows for an extra smooth shot!
If you want a potent shot, make a reverse Quaffer. Reverse the process: pour the alcohol in the bottom and the chaser on top = a double shot!
If you are at a party, set up a Quaffer station. This includes a Quaffer (or a few), some paper towels (or rags), the liquids of your choice, and most importantly, a full Quaffer. The trick here is to never allow the Quaffer to be by itself. Have someone pour you a Quaffer, after you drink yours, pour another one. Find someone and have them quaff-it down. Have them fill the Quaffer, find the next participant, and the party goes on. The rules are that you are not allowed to make your own Quaffer, and you can never leave a Quaffer empty. This will ensure that the party is a good one... trust me.